Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs

X Liu, H Yang, Z Liu - International Immunopharmacology, 2022 - Elsevier
Paraquat poisoning is a severe health problem globally, particularly in developing countries.
Due to its severe toxicity, the mortality rate of paraquat poisoning is greatly higher than other …

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis

R Subbiah, RR Tiwari - Critical reviews in Toxicology, 2021 - Taylor & Francis
Abstract The herbicide paraquat (PQ; 1, 1'-dimethyl-4, 4'-bipyridylium dichloride) is a highly
toxic organic heterocyclic herbicide that has been widely used in agricultural settings. Since …

[HTML][HTML] Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats

S Mehrzadi, I Fatemi, M Esmaeilizadeh… - Biomedicine & …, 2018 - Elsevier
Hepatotoxicity is one of the major side effects of methotrexate (MTX), which restricts the
clinical use of this drug. Berberine (BBR) is a natural compound with multiple …

Therapeutic potential of traditional Chinese medicine for interstitial lung disease

YM Zhou, XR Dong, D Xu, J Tang, YL Cui - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Interstitial lung disease (ILD) is a chronic lung dysfunction
disease with a poor prognosis and poor recovery. The clinically used therapeutic drugs …

[HTML][HTML] Evaluating the protective effects of melatonin on di (2-ethylhexyl) phthalate-induced testicular injury in adult mice

N Bahrami, M Goudarzi, A Hosseinzadeh… - Biomedicine & …, 2018 - Elsevier
Abstract Objective Di (2-ethylhexyl) phthalate (DEHP) is a common phthalate derivative,
interfering with normal function of reproductive system. The present study evaluated effects …

[HTML][HTML] Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway

ZD Zhang, YJ Yang, XW Liu, Z Qin, SH Li, JY Li - Toxicology, 2021 - Elsevier
Paraquat (PQ) is an effective and commercially important herbicide that is widely used
worldwide. However, PQ is highly toxic and can cause various complications and acute …

Natural product-based potential therapeutic interventions of pulmonary fibrosis

M Hasan, NC Paul, SK Paul, ASM Saikat, H Akter… - Molecules, 2022 - mdpi.com
Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of
mortality. The potential factors causing PF include viral infections, radiation exposure, and …

The role of natural products in the prevention and treatment of pulmonary fibrosis: a review

L Wang, S Li, Y Yao, W Yin, T Ye - Food & function, 2021 - pubs.rsc.org
Pulmonary fibrosis is an incurable end-stage lung disease and remains a global public
health problem. Although there have been some breakthroughs in understanding the …

[HTML][HTML] Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities

N Mohammadzadeh, S Mehri… - Iranian journal of basic …, 2017 - ncbi.nlm.nih.gov
Berberis vulgaris L (B. vulgaris) and its main constituent berberine have been used in
traditional medicine for a long time. This medicinal plant and berberine have many …

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

XN Tew, NJX Lau, DK Chellappan… - Chemico-biological …, 2020 - Elsevier
Inflammatory responses play a remarkable role in the mechanisms of acute and chronic
respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma …