About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

The natural lifespan of the ovary is occasionally interrupted by pathological processes; some
are known, but many are unknown. Premature ovarian insufficiency (POI) can be a …

Multiple changes occur across various endocrine systems as an individual ages. The
understanding of the factors that cause age-related changes and how they should be …

Premature ovarian insufficiency (POI) is the depletion of ovarian function before 40 years of
age due to insufficient oocyte formation or accelerated follicle atresia. Approximately 1–5 …

Context Premature ovarian insufficiency (POI) is characterized by cessation of menstruation
before 40 years of age and elevated serum level of FSH (> 25 IU/L). Recent studies have …

This review summarizes the existing information concerning the genetic background of
menopause and primary ovarian insufficiency (POI). There is overwhelming evidence that …

In previous studies, oxidative stress damage has been solely considered to be the
mechanism of ovarian aging, and several antioxidants have been used to delay ovarian …

To identify novel genes responsible for recurrent hydatidiform moles (HMs), we performed
exome sequencing on 75 unrelated patients who were negative for mutations in the known …

STUDY QUESTION What is the prevalence of somatic chromosomal instability among
women with idiopathic primary ovarian insufficiency (POI)? SUMMARY ANSWER A subset …