Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

The human genome contains over one million short tandem repeats. Expansion of a subset
of these repeat tracts underlies over fifty human disorders, including common genetic …

Although thousands of long non-coding RNAs (lncRNAs) are encoded in mammalian
genomes, their mechanisms of action are poorly understood, in part because they are often …

The C9ORF72-linked diseases amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) are characterized by the nuclear depletion and cytoplasmic accumulation of …

Objective Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic
fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG …

For most genes, mRNA transcript abundance scales with cell size to ensure a constant
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

Regulatory relationships between transcription factors (TFs) and their target genes lie at the
heart of cellular identity and function; however, uncovering these relationships is often labor …

The antiviral endoribonuclease, RNase L, is activated by the mammalian innate immune
response to destroy host and viral RNA to ultimately reduce viral gene expression. Herein …

The pentatricopeptide repeat (PPR) proteins constitute one of the largest nuclear-encoded
protein families in higher plants, with over 400 members in most sequenced plant species …