Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

The regulation of genome architecture is a key determinant of gene transcription patterns
and neural development. Advances in methodologies based on chromatin conformation …

Pericentromeric heterochromatin (PCH) gives rise to highly dense chromatin sub-structures
rich in the epigenetic mark corresponding to the trimethylated form of lysine 9 of histone H3 …

Pericentric heterochromatin (PCH) is a particular form of constitutive heterochromatin that is
localized to both sides of centromeres and that forms silent compartments enriched in …

Satellite DNAs are tandemly repeated sequences organized in large clusters within (peri)
centromeric and/or subtelomeric heterochromatin. However, in many species, satellite DNAs …

Background DNA methylation contributes to genomic integrity by suppressing repeat-
associated transposition. In addition to the canonical DNA methyltransferases, several …

Summary Methyl-CpG binding protein 2 (MeCP2) has historically been linked to
heterochromatin organization, and in mouse cells it accumulates at pericentric …

During embryonic development, stem cells undergo the differentiation process so that they
can specialize for different functions within the organism. Complex programs of gene …

Results Nuclear Tau interacts with PCH in primary cultured neurons. To investigate the
subnuclear distribution of Tau protein with respect to PCH in neurons, we carried out an …

Au cours de cette thèse j'ai développé des compétences techniques, comme cultiver des
cellules pour en extraire leur ADN et peut-être (je dis bien peut-être) des réponses qui vont …