The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially
superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as …

Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules
known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from …

Objectives: Ellagic acid (EA) has shown antinociceptive and anti-inflammatory effects.
Inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2) enzymes and also …

Analytical and immunological methodologies and occasionally both methodologies have
been applied to detect and quantify 3-nitrotyrosine in almost every major organ system. In …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

Peroxynitrite is a reactive oxidant produced from nitric oxide (NO) and superoxide, which
reacts with a variety of biomolecules including proteins, lipids and DNA. Peroxynitrite is …

We have investigated the anti‐inflammatory effects of Cinnamomum cassia constituents
(cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using …

The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the
detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite …