Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …
health. Their disruption is associated with detrimental physiological consequences …
Transcriptional architecture of the mammalian circadian clock
JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
The Rotterdam Study: 2018 update on objectives, design and main results
MA Ikram, GGO Brusselle, SD Murad… - European journal of …, 2017 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
GWAS identifies 14 loci for device-measured physical activity and sleep duration
A Doherty, K Smith-Byrne, T Ferreira… - Nature …, 2018 - nature.com
Physical activity and sleep duration are established risk factors for many diseases, but their
aetiology is poorly understood, partly due to relying on self-reported evidence. Here we …
aetiology is poorly understood, partly due to relying on self-reported evidence. Here we …
[HTML][HTML] Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications
Links between short sleep duration and obesity, type 2 diabetes, hypertension, and
cardiovascular disease may be mediated through changes in dietary intake. This review …
cardiovascular disease may be mediated through changes in dietary intake. This review …
Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour
Sleep is an essential human function but its regulation is poorly understood. Using
accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide …
accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide …
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Sleep is an essential state of decreased activity and alertness but molecular factors
regulating sleep duration remain unknown. Through genome-wide association analysis in …
regulating sleep duration remain unknown. Through genome-wide association analysis in …
Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci
Disrupted circadian rhythms and reduced sleep duration are associated with several human
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
JM Lane, J Liang, I Vlasac, SG Anderson… - Nature …, 2017 - nature.com
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
[HTML][HTML] Chronotype: implications for epidemiologic studies on chrono-nutrition and cardiometabolic health
S Almoosawi, S Vingeliene, F Gachon, T Voortman… - Advances in …, 2019 - Elsevier
Chrono-nutrition is an emerging research field in nutritional epidemiology that encompasses
3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have …
3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have …