[HTML][HTML] A guide to the organ-on-a-chip
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
[HTML][HTML] Targeting tumor microenvironment for cancer therapy
C Roma-Rodrigues, R Mendes, PV Baptista… - International journal of …, 2019 - mdpi.com
Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …
progressing from academic proof-of-concept studies to valid solutions to real-world …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening
Microfluidic technologies employ nano and microscale fabrication techniques to develop
highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead …
highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead …
3D bioprinting of tumor models for cancer research
The exact mechanistic understanding of cancer metastasis continues to be unknown,
although it is a major cause of death worldwide. Along with the tumor mass, the tumor …
although it is a major cause of death worldwide. Along with the tumor mass, the tumor …
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors
Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
[HTML][HTML] Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …
technologies have enabled the recapitulation of the major functions and architectures of …
The emergence of 3D bioprinting in organ-on-chip systems
Understanding complex cell–cell interactions and physiological microenvironments is critical
for the development of new therapies for treating human diseases. Current animal models …
for the development of new therapies for treating human diseases. Current animal models …
Single‐cell nanoencapsulation: From passive to active shells
Single‐cell nanoencapsulation is an emerging field in cell‐surface engineering,
emphasizing the protection of living cells against external harmful stresses in vitro and in …
emphasizing the protection of living cells against external harmful stresses in vitro and in …