Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

One week after fertilization, human embryos implant into the uterus. This event requires the
embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo …

The relationship between the human placenta—the extraembryonic organ made by the
fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect …

Recurrent pregnancy loss is a distressing pregnancy disorder experienced by~ 2.5% of
women trying to conceive. Recurrent pregnancy loss is defined as the failure of two or more …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

Three-dimensional cell and organoid cultures rely on the mechanical support of viscoelastic
matrices. However, commonly used matrix materials lack control over key cell-instructive …