Signal pathways of melanoma and targeted therapy
W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer
G Zhu, L Pei, H Xia, Q Tang, F Bi - Molecular cancer, 2021 - Springer
Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels.
Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in …
Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in …
RAS-targeted therapies: is the undruggable drugged?
AR Moore, SC Rosenberg, F McCormick… - Nature reviews Drug …, 2020 - nature.com
Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
ME Bahar, HJ Kim, DR Kim - Signal transduction and targeted therapy, 2023 - nature.com
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …
underscores the urgent need for enhanced insights into the molecular and cellular …
Integrated proteogenomic characterization across major histological types of pediatric brain cancer
We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling
KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a
longtime goal. Recently, inhibitors were developed that bind KRASG12C-GDP and react …
longtime goal. Recently, inhibitors were developed that bind KRASG12C-GDP and react …
Targeting alterations in the RAF–MEK pathway
R Yaeger, RB Corcoran - Cancer discovery, 2019 - AACR
The MAPK pathway is one of the most commonly mutated oncogenic pathways in cancer.
Although RAS mutations are the most frequent MAPK alterations, less frequent alterations in …
Although RAS mutations are the most frequent MAPK alterations, less frequent alterations in …
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
I Landa, T Ibrahimpasic, L Boucai… - The Journal of …, 2016 - Am Soc Clin Investig
BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident
INTRODUCTION The 1986 Chernobyl (Chornobyl in Ukrainian) nuclear power plant
accident exposed millions of individuals in the surrounding region to radioactive …
accident exposed millions of individuals in the surrounding region to radioactive …
Integrated genomic characterization of papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …