Genome-wide functional genetic screens have been successful in discovering genotype-
phenotype relationships and in engineering new phenotypes. While broadly applied in …

BACKGROUND An increasing human population, the emergence of resistances against
pesticides and their potential impact on the environment call for the development of new eco …

Gene essentiality is defined as the extent to which a gene is required for the survival and
reproductive success of a living system. It can vary between genetic backgrounds and …

Gene essentiality is a genetic concept crucial for a comprehensive understanding of life and
evolution. In the last decade, many essential genes (EGs) have been determined using …

The identification and characterization of essential genes are central to our understanding of
the core biological functions in eukaryotic organisms, and has important implications for the …

Over the years, comprehensive explorations of the model organisms Caenorhabditis
elegans (elegant worm) and Drosophila melanogaster (vinegar fly) have contributed …

Machine learning-based approaches are particularly suitable for identifying essential genes
as they allow the generation of predictive models trained on features from multi-source data …

Increasing reports of insecticide resistance continue to hamper the gains of vector control
strategies in curbing malaria transmission. This makes identifying new insecticide targets or …

Detailed explorations of the model organisms Caenorhabditis elegans (elegant worm) and
Drosophila melanogaster (vinegar fly) have substantially improved our knowledge and …

Expanding antiviral treatment options against SARS-CoV-2 remains crucial as the virus
evolves under selection pressure which already led to the emergence of several drug …