Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …

Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
deposition of amyloids in the brain. One prominent form of amyloid is composed of repeating …

Aggregation of amyloid β-peptide (Aβ) is implicated in the pathology of Alzheimer's disease
(AD), with the soluble, Aβ oligomeric species thought to be the critical pathological species …

Different amyloid beta (Aβ) aggregates can be discriminated by a combinatorial fluorescent
molecular sensor. The unique optical fingerprints generated by the unimolecular analytical …

The aggregation of proteins into insoluble amyloid fibrils coincides with the onset of
numerous diseases. An array of techniques is available to study the different stages of the …

Impairment of the protein quality control network leads to the accumulation of unfolded and
aggregated proteins. Direct detection of unfolded protein accumulation in the cells may …

The abnormal aggregation of β-amyloid (Aβ) peptides in the brain is a major pathological
hallmark of Alzheimer's disease (AD). The suppression (or alteration) of Aβ aggregation is …

Increasing evidence supports the hypothesis that soluble misfolded protein assemblies
contribute to the degeneration of postmitotic tissue in amyloid diseases. However, there is a …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative disorders, characterized by aggregation of amyloid polypeptides, β …

Amyloid-beta (Aβ) oligomers have been become believable biomarkers for predicting and
diagnosing Alzheimer's disease (AD). Herein, an ultrasensitive electrochemical assay for …