The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

An increasingly recognized component of resistance to tyrosine kinase inhibitors (TKI)
involves persistence of a drug-tolerant subpopulation of cancer cells that survive despite …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. To date, no medication has been approved to treat NAFLD. In this study, we …

Discrimination between properly folded proteins and those that do not reach this state is
necessary for cells to achieve functionality. Eukaryotic cells have evolved several …

Secretory and membrane proteins are folded in the endoplasmic reticulum (ER) prior to their
exit. When ER function is disturbed by exogenous and endogenous factors, such as heat …

The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) signaling pathway
was reported to exert an important role in neuronal apoptosis. The present study was …

As powerful bioactive compounds found in a variety of plant-based foods,(epi) catechins
have been identified to be associated with an abundant array of health benefits. While their …

The protein kinase R-like endoplasmic reticulum kinase/eukaryotic initiation factor 2ɑ
(PERK/eIF2α), the branch of unfolded protein response (UPR), is responsible for transient …

Diabetes mellitus is a chronic metabolic disorder, resulting in high morbidity and mortality
worldwide. Neuropathy, ocular diseases, kidney diseases, and cardiovascular disease are …