Plant molecular farming: A viable platform for recombinant biopharmaceutical production

B Shanmugaraj, CJ I. Bulaon, W Phoolcharoen - Plants, 2020 - mdpi.com
The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing
steadily, which is attracting global attention for the development of new recombinant protein …

[HTML][HTML] Therapeutic glycoprotein production in mammalian cells

ME Lalonde, Y Durocher - Journal of biotechnology, 2017 - Elsevier
Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …

Plant protein glycosylation

R Strasser - Glycobiology, 2016 - academic.oup.com
Protein glycosylation is an essential co-and post-translational modification of secretory and
membrane proteins in all eukaryotes. The initial steps of N-glycosylation and N-glycan …

The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons

J Bally, H Jung, C Mortimer, F Naim… - Annual review of …, 2018 - annualreviews.org
A decade ago, the value of Nicotiana benthamiana as a tool for plant molecular biologists
was beginning to be appreciated. Scientists were using it to study plant-microbe and protein …

The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

NA Pereira, KF Chan, PC Lin, Z Song - MAbs, 2018 - Taylor & Francis
Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics
for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy …

Plant-based biopharmaceutical engineering

L Eidenberger, B Kogelmann… - Nature Reviews …, 2023 - nature.com
Plants can be engineered to recombinantly produce high-quality proteins such as
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …

A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus

BM Gunn, WH Yu, MM Karim, JM Brannan… - Cell host & …, 2018 - cell.com
The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …

Impact of host cell line choice on glycan profile

JB Goh, SK Ng - Critical reviews in biotechnology, 2018 - Taylor & Francis
Protein glycosylation is post-translational modification (PTM) which is important for
pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result …

Plants as sources of natural and recombinant anti-cancer agents

JF Buyel - Biotechnology advances, 2018 - Elsevier
Herbal remedies were the first medicines used by humans due to the many
pharmacologically active secondary metabolites produced by plants. Some of these …

[HTML][HTML] Plants as factories for human pharmaceuticals: applications and challenges

J Yao, Y Weng, A Dickey, KY Wang - International journal of molecular …, 2015 - mdpi.com
Plant molecular farming (PMF), defined as the practice of using plants to produce human
therapeutic proteins, has received worldwide interest. PMF has grown and advanced …