Plant molecular farming: A viable platform for recombinant biopharmaceutical production
B Shanmugaraj, CJ I. Bulaon, W Phoolcharoen - Plants, 2020 - mdpi.com
The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing
steadily, which is attracting global attention for the development of new recombinant protein …
steadily, which is attracting global attention for the development of new recombinant protein …
[HTML][HTML] Therapeutic glycoprotein production in mammalian cells
ME Lalonde, Y Durocher - Journal of biotechnology, 2017 - Elsevier
Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …
production towards mammalian cell expression systems. The presence of glycosylation …
Plant protein glycosylation
R Strasser - Glycobiology, 2016 - academic.oup.com
Protein glycosylation is an essential co-and post-translational modification of secretory and
membrane proteins in all eukaryotes. The initial steps of N-glycosylation and N-glycan …
membrane proteins in all eukaryotes. The initial steps of N-glycosylation and N-glycan …
The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons
A decade ago, the value of Nicotiana benthamiana as a tool for plant molecular biologists
was beginning to be appreciated. Scientists were using it to study plant-microbe and protein …
was beginning to be appreciated. Scientists were using it to study plant-microbe and protein …
The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity
NA Pereira, KF Chan, PC Lin, Z Song - MAbs, 2018 - Taylor & Francis
Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics
for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy …
for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy …
Plant-based biopharmaceutical engineering
L Eidenberger, B Kogelmann… - Nature Reviews …, 2023 - nature.com
Plants can be engineered to recombinantly produce high-quality proteins such as
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …
A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus
The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …
Impact of host cell line choice on glycan profile
JB Goh, SK Ng - Critical reviews in biotechnology, 2018 - Taylor & Francis
Protein glycosylation is post-translational modification (PTM) which is important for
pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result …
pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result …
Plants as sources of natural and recombinant anti-cancer agents
JF Buyel - Biotechnology advances, 2018 - Elsevier
Herbal remedies were the first medicines used by humans due to the many
pharmacologically active secondary metabolites produced by plants. Some of these …
pharmacologically active secondary metabolites produced by plants. Some of these …
[HTML][HTML] Plants as factories for human pharmaceuticals: applications and challenges
J Yao, Y Weng, A Dickey, KY Wang - International journal of molecular …, 2015 - mdpi.com
Plant molecular farming (PMF), defined as the practice of using plants to produce human
therapeutic proteins, has received worldwide interest. PMF has grown and advanced …
therapeutic proteins, has received worldwide interest. PMF has grown and advanced …