Fine-tuning of GPCR activity by receptor-interacting proteins
SL Ritter, RA Hall - Nature reviews Molecular cell biology, 2009 - nature.com
G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …
Regulation of GPCR activity, trafficking and localization by GPCR‐interacting proteins
AC Magalhaes, H Dunn… - British journal of …, 2012 - Wiley Online Library
GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …
Regulation of receptor trafficking by GRKs and arrestins
CAC Moore, SK Milano, JL Benovic - Annu. Rev. Physiol., 2007 - annualreviews.org
To ensure that extracellular stimuli are translated into intracellular signals of appropriate
magnitude and specificity, most signaling cascades are tightly regulated. One of the major …
magnitude and specificity, most signaling cascades are tightly regulated. One of the major …
Regulation of GPCRs by endocytic membrane trafficking and its potential implications
AC Hanyaloglu, M Zastrow - Annu. Rev. Pharmacol. Toxicol., 2008 - annualreviews.org
The endocytic pathway tightly controls the activity of G protein–coupled receptors (GPCRs).
Ligand-induced endocytosis can drive receptors into divergent lysosomal and recycling …
Ligand-induced endocytosis can drive receptors into divergent lysosomal and recycling …
Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain
Dopamine D2 receptors are involved with wakefulness, but their role in the decreased
alertness associated with sleep deprivation is unclear. We had shown that sleep deprivation …
alertness associated with sleep deprivation is unclear. We had shown that sleep deprivation …
[HTML][HTML] Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain
Caffeine, the most widely consumed psychoactive substance in the world, is used to
promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants …
promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants …
Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors
A Anzalone, JE Lizardi-Ortiz, M Ramos… - Journal of …, 2012 - Soc Neuroscience
Dysfunctions of dopaminergic homeostasis leading to either low or high dopamine (DA)
levels are causally linked to Parkinson's disease, schizophrenia, and addiction. Major sites …
levels are causally linked to Parkinson's disease, schizophrenia, and addiction. Major sites …
[HTML][HTML] Functional implications of dopamine D1 vs. D2 receptors: a 'prepare and select'model of the striatal direct vs. indirect pathways
The functions of the D1-and D2-dopamine receptors in the basal ganglia have remained
somewhat enigmatic, with a number of competing theories relating to the interactions of the …
somewhat enigmatic, with a number of competing theories relating to the interactions of the …
Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine–International Restless Legs …
OBJECTIVES: Augmentation of symptom severity is the main complication of dopaminergic
treatment of restless legs syndrome (RLS). The current article reports on the considerations …
treatment of restless legs syndrome (RLS). The current article reports on the considerations …
The dopamine D4 receptor: biochemical and signalling properties
P Rondou, G Haegeman… - Cellular and molecular life …, 2010 - Springer
Dopamine is an important neurotransmitter that regulates several key functions in the brain,
such as motor output, motivation and reward, learning and memory, and endocrine …
such as motor output, motivation and reward, learning and memory, and endocrine …