Complexity of dopamine metabolism
Parkinson's disease (PD) coincides with a dramatic loss of dopaminergic neurons within the
substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress …
substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress …
Pterin-dependent amino acid hydroxylases
TJ Kappock, JP Caradonna - Chemical reviews, 1996 - ACS Publications
Tetrahydrobiopterin-dependent systems occupy several interesting niches in biological
chemistry, as metalloproteins that activate O2 for highly specific oxidations, as regulators for …
chemistry, as metalloproteins that activate O2 for highly specific oxidations, as regulators for …
Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases
KE Goodwill, C Sabatier, C Marks, R Raag… - Nature structural …, 1997 - nature.com
Tyrosine hydroxylase (TyrOH) catalyzes the conversion of tyrosine to L-DOPA, the rate-
limiting step in the biosynthesis of the catecholamines dopamine, adrenaline, and …
limiting step in the biosynthesis of the catecholamines dopamine, adrenaline, and …
Complex molecular regulation of tyrosine hydroxylase
I Tekin, R Roskoski, N Carkaci-Salli… - Journal of neural …, 2014 - Springer
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, is strictly
controlled by several interrelated regulatory mechanisms. Enzyme synthesis is controlled by …
controlled by several interrelated regulatory mechanisms. Enzyme synthesis is controlled by …
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene …
T Nagatsu, I Nagatsu - Journal of neural transmission, 2016 - Springer
Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in
1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and …
1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and …
[PDF][PDF] Structural insight into the aromatic amino acid hydroxylases and their disease-related mutant forms
T Flatmark, RC Stevens - Chemical reviews, 1999 - academia.edu
The mammalian aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan
hydroxylase (PheOH, TyrOH, TrpOH, respectively)) are functionally and structurally closely …
hydroxylase (PheOH, TyrOH, TrpOH, respectively)) are functionally and structurally closely …
CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation
YY Ou, GJ Mack, M Zhang… - Journal of cell …, 2002 - journals.biologists.com
The mammalian centrosome consists of a pair of centrioles surrounded by pericentriolar
material (PCM). The architecture and composition of the centrosome, especially the PCM …
material (PCM). The architecture and composition of the centrosome, especially the PCM …
Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3
IWL Leung, N Lassam - Journal of Biological Chemistry, 1998 - ASBMB
Mixed lineage kinase-3 (MLK-3) is a mitogen-activated kinase kinase kinase that mediates
stress-activating protein kinase (SAPK)/c-Jun NH 2-terminal kinase activation. MLK-3 and …
stress-activating protein kinase (SAPK)/c-Jun NH 2-terminal kinase activation. MLK-3 and …
Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association …
G Stöber, MM Nöthen, P Pörzgen… - American journal of …, 1996 - Wiley Online Library
The complete coding region of the norepinephrine transporter (NET) gene was
systematically screened for genetic variants in 137 unrelated individuals (including 46 …
systematically screened for genetic variants in 137 unrelated individuals (including 46 …
Structure/function relationships in human phenylalanine hydroxylase: effect of terminal deletions on the oligomerization, activation and cooperativity of substrate …
PM Knappskog, T Flatmark, JM Aarden… - European journal of …, 1996 - Wiley Online Library
Amino‐terminal and carboxy‐terminal deletion mutagenesis have been used to identify
structurally and functionally critical regions of recombinant wild‐type human phenylalanine …
structurally and functionally critical regions of recombinant wild‐type human phenylalanine …