Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …

There is ample pathological and biological evidence for endo-lysosomal dysfunction in
Alzheimer's disease (AD) and emerging genetic studies repeatedly implicate endo …

Lysosomal dysfunction is a pathogenic link that may explain the causal relationship between
diabetes and Alzheimer disease; however, there is no information about the regulation of …

The decades of evidence that showcase the role of amyloid precursor protein (APP), and its
fragment amyloidβ (Aβ), in Alzheimer's disease (AD) pathogenesis are irrefutable. However …

Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin
D manages protein turnover degrading misfolded and aggregated proteins and favors …

The disturbance in mitochondrial functions and homeostasis are the major features of
neuron degenerative conditions, like Parkinson's disease, Amyotrophic Lateral Sclerosis …

Microglia are the professional immune cells of the brain, which support numerous
physiological processes. One of the defensive functions provided by microglia involves …

Many hypotheses have been postulated to define the etiology of sporadic Parkinson's and
Alzheimer's disorders (PD and AD) but there is no consensus on what causes these …

The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition
core complex which regulates intracellular protein sorting and trafficking. Deficiency in …