Age-related diseases for which there are no effective treatments include cardiovascular
diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as …

Patients with decompensated cirrhosis are currently managed through targeted strategies
aimed at preventing or treating specific complications. In contrast, a disease-modifying agent …

Recent studies have demonstrated that metabolites produced by commensal bacteria
causally influence health and disease. The sulfated metabolome is one class of molecules …

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …

Abstract Cholestane-3β, 5α, 6β-triol (CT) is a primary metabolite of 5, 6-epoxycholesterols
(5, 6-EC) that is catalyzed by the cholesterol-5, 6-epoxide hydrolase (ChEH). CT is a well …

Context Clinical hypothyroidism (CH) and subclinical hypothyroidism (SCH) have been
linked to various metabolic comorbidities but the underlying metabolic alterations remain …

Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol
essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the …

Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate
the physiology of cells, including those of the immune system. In contrast to effects that are …

Oxysterols have long been believed to be ligands of nuclear receptors such as liver×
receptor (LXR), and they play an important role in lipid homeostasis and in the immune …

Ambient temperature is an important determinant of both the alternative bile acid synthesis
pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic …