Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …

The zinc finger transcription factor gene, CASZ1/Castor (Castor zinc finger 1), initially
identified in Drosophila, plays a critical role in neural, cardiac, and cardiovascular …

Varicose veins is the most common manifestation of chronic venous disease that displays
female-biased incidence. To identify protein-inactivating variants that could guide …

Summary Four genes—DAND5, PKD1L1, MMP21, and CIROP—form a genetic module that
has specifically evolved in vertebrate species that harbor motile cilia in their left-right …

Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing
variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as …

Venous valve (VV) failure causes chronic venous insufficiency, but the molecular regulation
of valve development is poorly understood. A primary lymphatic anomaly, caused by …

Varicose veins (VVs) are the most common manifestation of chronic venous disease (CVD)
and appear as abnormally enlarged and tortuous superficial veins. VVs result from …

Background/Objectives: Chronic venous insufficiency (CVI), a chronic vascular dysfunction,
is a common health problem that causes serious complications such as painful varicose …

Objectives: Describe the etiology of varicose veins. List the factors associated with an
increased risk of developing varicose veins. Describe exam findings consistent with varicose …

Summary Four genes—DAND5, PKD1L1, MMP21, and CIROP—form a genetic module that
has specifically evolved in vertebrate species that harbor motile cilia in their left-right …