It has recently become possible to characterize a variety of different receptors by studying
the binding of appropriate drugs labelled with 3 H or 125 I. The goal of this review is to …

Cenobamate is a novel antiepileptic drug under investigation for use in patients with focal
(partial-onset) seizures. To understand its potential molecular mechanism of action, the …

An essential element of the signalling cascade leading to synaptic plasticity is the
intracellular second messenger molecule guanosine 3′, 5′-cyclic monophosphate …

Abstract The [3 H] PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-
isoquinolinecarboxamide, binding sites in rat cardiac membranes are saturable, with high …

A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells
(RBCs) in circulation. Loss of potassium (K+), chloride (Cl−), and water from RBCs is thought …

Electrophysiology of BZR ligands has been reviewed from different points of view. A great
effort was made to critically discuss the arguments for and against the temporarily leading …

Abstract The steroid hormone, 1, 25-dihydroxycholecalciferol (1, 25-(OH) 2D3) causes the
de novo synthesis of a calcium-binding protein (D-CaBP) 1, 2. This protein is present in …

A representative of a novel series of imidazodiazepines, Ro 15-1788, selectively
antagonizes all major central actions of benzodiazepines by competitive, high-affinity …

Brain-specific binding sites have been isolated on synaptosomal membrane fragments
which recognize pharmacologically active benzodiazepine (BDZ's) and triazolopyridazines …

We have investigated the effects of 2-ethylamino-6-chloro-4-methyl-4-phenyl-4H-3, 1-
benzoxazine hydrochloride (etifoxine) on GABAA receptor function. Etifoxine displaced [35S] …