Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …

The intimate connection, both physical and biochemical, between blood vessels and bone
cells has long been recognized. Genetic, biochemical, and pharmacological studies have …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

The therapeutic use of autologous platelet-rich plasma constitutes a relatively new
biotechnology that has been a breakthrough in the stimulation and acceleration of soft-tissue …

Blood platelets become activated and aggregate at the site of vessel injury. Upon activation
by thrombin, platelets release storage pools of proteins and growth factors (GFs), including …

Recent studies have indicated a critical role for vascular endothelial growth factor (VEGF)
during the process of endochondral ossification, in particular in coupling cartilage resorption …

During fracture healing, multipotential stem cells differentiate into specialized cells
responsible for producing the different tissues involved in the bone regeneration process …

It has become well accepted that solid tumors must create a vascular system for nutrient
delivery and waste removal in order to grow appreciably. This process, angiogenesis, is …

Statins such as simvastatin are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
that inhibit cholesterol synthesis. We presently investigated statin effects on vascular …