Design and Synthesis of some new 2, 4, 6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents

HA Allam, EE Aly, AK Farouk, AM El Kerdawy… - Bioorganic …, 2020 - Elsevier
The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …

Tryptanthrin and its derivatives in drug discovery: synthetic insights

P Brandão, M Pineiro, AJ Burke - Synthesis, 2022 - thieme-connect.com
Tryptanthrin is a golden-yellow, naturally occurring alkaloid that can be obtained from
multiple sources and through different synthetic methodologies. This tetracyclic compound …

Recent advances of tryptanthrin and its derivatives as potential anticancer agents

X Zhou - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
Tryptanthrin is one of the well-known natural alkaloids with the broader spectrum of
biological activities as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral …

Novel tryptanthrin hybrids bearing aminothiazoles as potential EGFR inhibitors: Design, synthesis, biological screening, molecular docking studies, and ADME/T …

R Palabindela, R Guda, G Ramesh… - Journal of …, 2022 - Wiley Online Library
A variety of novel tryptanthrin aminothiazole analogues 3a‐h and 5a‐h possessing a
biologically active thiazole moiety were synthesized by the reaction of tryptanthrin …

Visible-light promoted catalyst-free (VLCF) multi-component synthesis of spiro indolo-quinazolinone-pyrrolo[3,4-a]pyrrolizine hybrids: evaluation of in vitro anticancer …

S Iqbal, Farhanaz, Roohi, MR Zaheer… - Journal of …, 2024 - Taylor & Francis
A new and highly efficient visible-light-promoted catalyst free (VLCF) strategy for neat and
clean synthesis of spiro indolo-quinazolinone-pyrrolo [3, 4-a] pyrrolizine hybrids (6a–d) has …

A convenient synthesis of spiroindolo[2,1-b]quinazoline-6,2′-[1,3,4]oxadiazoles from tryptanthrin and nitrile imines

I Yavari, M Askarian-Amiri, Z Taheri - Monatshefte für Chemie-Chemical …, 2019 - Springer
A convenient method for the synthesis of functionalized spiroindolo [2, 1-b] quinazoline-6,
2′-[1, 3, 4] oxadiazoles from indolo [2, 1-b] quinazoline-6, 12-diones and 13 hydrazonoyl …

Design, Synthesis, and Biological Evaluation of Tryptanthrin Alkaloids as Potential anti-Diabetic and Anticancer Agents

C Teja, K Ramanathan, K Naresh, R Vidya… - Polycyclic Aromatic …, 2023 - Taylor & Francis
An efficient green chemical approach has been reported to synthesize tryptanthrin alkaloids,
utilizing isatin and isatoic anhydride as a substrate in the presence of tetrabutylammonium …

[PDF][PDF] Antitumor Effects of Vanillin Based Chalcone Analogues In Vitro

J Luković, M Mitrović, S Popović… - Acta Poloniae …, 2020 - bibliotekanauki.pl
Chalcones, as a large group of organic compounds, are widely implemented in various
types of anti-cancer therapeutics. These plant metabolites are present in fruits, vegetables …

Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate

AR Kovrizhina, AA Kolpakova, AA Kuznetzov… - Molbank, 2022 - mdpi.com
Indolo [2, 1-b] quinazolin-6, 12-dione (tryptanthrin) derivatives present important types of
nitrogen-containing heterocyclic compounds which are useful intermediate products in …

Synthesis, Characterization and Biological Applications of Substituted Indolo [2, 1-b] quinazolin-12 (6H)-one Based Rhenium (I) Organometallic Compounds.

AD Padariya, NK Savaliya, MP Dhaduk… - Acta Chimica …, 2024 - search.ebscohost.com
The Re (I) organometallic compounds [(Re (CO) 3L1–6) Cl], where ligands L are tryptanthrin
derivatives, prepared and characterized by various spectroscopic techniques. To assess the …