Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is the key enzyme of
cholesterol synthesis. HMG-CoA reductase inhibitors are potent reversible inhibitors of this …

Intestinal cholesterol absorption represents a major route for the entry of cholesterol into the
body's miscible pools and therefore can potentially impact the plasma LDL-cholesterol …

Gallstones or cholelithiasis are a major public health problem in Europe and other
developed countries and affect up to 20% of the population. Gallstone disease is the most …

Background—Despite the established efficacy of statins, many patients do not achieve
recommended LDL cholesterol (LDL-C) goals. Contributing factors may be inadequate …

Dr. DeWitt Goodman had agreed to be a member of this second Adult Treatment Panel at
the time of his dismayingly early death in November 1991. Dr. Goodman served with …

Legume consumption appears to lower serum cholesterol and to increase cholesterol
saturation of bile, but the mechanisms of these effects have not been established. We …

BACKGROUND & AIMS: Statins can reduce biliary cholesterol secretion independently of
their ability to inhibit cholesterol synthesis. Statins also prevent the formation of gallstones in …

Purpose The aim of this study was to evaluate the efficacy and tolerability of
rosuvastatin/ezetimibe combination therapy in Korean patients with high cardiovascular risk …

Cholesterol gallstone disease, one of the commonest digestive diseases in western
countries, is induced by an imbalance in cholesterol metabolism, which involves intestinal …

Our results showed that α-asarone was an inhibitor of hepatic HMG-CoA reductase and that
the administration of α-asarone at 80 mg/kg body wt. for 8 days decreased serum cholesterol …