Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important
cause of mortality in the general population. Genetic studies conducted during the past 20 …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

This review presents an extensively integrated model of the cardiac intercalated disc (ID), a
highly orchestrated structure that connects adjacent cardiomyocytes. Classically, three main …

The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring
the importance of understanding factors contributing to normal and abnormal electrical …

The cardiac sodium channel NaV1. 5, encoded by the SCN5A gene, is responsible for the
fast upstroke of the action potential. Mutations in SCN5A may cause sodium channel …

This review summarizes data in support of the notion that the cardiac intercalated disc is the
host of a protein interacting network, called “the connexome”, where molecules classically …

Epidemiologic studies clearly document the public health burden of sudden unexpected
death in epilepsy (SUDEP). Clinical and experimental studies have uncovered dynamic …

Genetic conditions, even those associated with identical gene mutations, can present with
variable clinical manifestations. One widely accepted explanation for this phenomenon is …

In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α‐
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …

Rationale: Loss-of-function of the cardiac sodium channel NaV1. 5 causes conduction
slowing and arrhythmias. NaV1. 5 is differentially distributed within subcellular domains of …