Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Heavy-atom-free photosensitizers: from molecular design to applications in the photodynamic therapy of cancer

VN Nguyen, Y Yan, J Zhao, J Yoon - Accounts of chemical …, 2020 - ACS Publications
Conspectus Photodynamic therapy (PDT) is a clinically approved therapeutic modality that
has shown great potential for the treatment of cancers owing to its excellent spatiotemporal …

Photosensitizers for photodynamic therapy

M Lan, S Zhao, W Liu, CS Lee… - Advanced healthcare …, 2019 - Wiley Online Library
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes
advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by …

ER-targeting cyanine dye as an NIR photoinducer to efficiently trigger photoimmunogenic cancer cell death

H Ma, Y Lu, Z Huang, S Long, J Cao… - Journal of the …, 2022 - ACS Publications
Endoplasmic reticulum (ER) stress, caused by overproduction of reactive oxygen species
(ROS), has been shown to be responsible for immunogenic cell death (ICD). Seeking ROS …

Luminescent radicals

A Mizuno, R Matsuoka, T Mibu, T Kusamoto - Chemical Reviews, 2024 - ACS Publications
Organic radicals are attracting increasing interest as a new class of molecular emitters. They
demonstrate electronic excitation and relaxation dynamics based on their doublet or higher …

Evolution of BODIPY as triplet photosensitizers from homogeneous to heterogeneous: The strategies of functionalization to various forms and their recent applications

D Wang, X Wang, S Zhou, P Gu, X Zhu, C Wang… - Coordination Chemistry …, 2023 - Elsevier
The BODIPY chromophore is one of the most versatile fluorophore building blocks in various
research fields, especially in life science and material science. It has attracted substantial …

Molecular design of highly efficient heavy‐atom‐free triplet BODIPY derivatives for photodynamic therapy and bioimaging

VN Nguyen, Y Yim, S Kim, B Ryu… - Angewandte Chemie …, 2020 - Wiley Online Library
Novel BODIPY photosensitizers were developed for imaging‐guided photodynamic therapy.
The introduction of a strong electron donor to the BODIPY core through a phenyl linker …

Heavy-atom-free BODIPY photosensitizers with intersystem crossing mediated by intramolecular photoinduced electron transfer

MA Filatov - Organic & Biomolecular Chemistry, 2020 - pubs.rsc.org
Organic photosensitizers possessing efficient intersystem crossing (ISC) and forming long-
living triplet excited states, play a crucial role in a number of applications. A common …

Strategies to construct efficient singlet oxygen-generating photosensitizers

E Pang, S Zhao, B Wang, G Niu, X Song… - Coordination Chemistry …, 2022 - Elsevier
Abstract Singlet oxygen (1 O 2) generation is an essential function of photosensitizer (PS) as
applied to photodynamic therapy (PDT) of cancer. As illustrated in the Jablonski diagram …