For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells
represents an important cell source for diabetes research. Here, we fully characterized iPSC …

Direct lineage reprogramming of one somatic cell into another without transitioning through
a progenitor stage has emerged as a strategy to generate clinically relevant cell types. One …

Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by
high blood glucose levels either due to an absolute deficiency of insulin secretion or an …

Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid
technologies have rapidly advanced, leading to the emergence of bioengineering islet …

Transplantation of insulin-secreting cells provides a promising method for re-establishing
the autonomous blood glucose control ability of type 1 diabetes (T1D) patients, but the low …

Although several synthetic hydrogels with defined stiffness have been developed to facilitate
the proliferation and maintenance of human pluripotent stem cells (hPSCs), the influence of …

The unlimited proliferative capacity of human pluripotent stem cells (hPSCs) fortifies it as
one of the most attractive sources for cell therapy application in diabetes. In the past two …

Transplantation of stem cell-derived β-cells is a promising therapeutic advancement in the
treatment of type 1 diabetes mellitus. A current limitation of this approach is the long …