Over a century ago, Theodor Boveri paved the way to mechanistic studies linking
chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical …

DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells.
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …

Micronuclei (MN) are small, extranuclear bodies that arise in dividing cells from acentric
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …

The formation of micronuclei (MN) is extensively used in molecular epidemiology as a
biomarker of chromosomal damage, genome instability, and eventually of cancer risk. The …

Background DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are
present in cells to process DNA damage and prevent genomic instability caused by various …

Purpose: To develop a simple method for the quantification of γ-H2AX focus number, density
and size. Methods: MDA-MB-468 human breast cancer cells were treated overnight with …

PURPOSE: Several in vitro studies suggest that BRCA1 and BRCA2 mutation carriers
present increased sensitivity to ionizing radiation. Different assays for the assessment of …

The scoring of micronuclei (MN) is widely used in biomonitoring and mutagenicity testing as
a surrogate marker of chromosomal damage inflicted by clastogenic agents or by aneugens …

The Auger electron–emitting radiopharmaceutical 111In-diethylenetriaminepentaacetic acid
human epidermal growth factor (111In-DTPA-hEGF) binds the epidermal growth factor …

The ability to repair DNA damage is strongly associated with the risk of cancer and other
human diseases as it is essential for maintenance of genome stability. Moreover, DNA repair …