Whole-genome sequencing (WGS) of pathogens is becoming increasingly important not
only for basic research but also for clinical science and practice. In virology, WGS is …

Although a fundamental understanding of the pathogenicity of most biothreat agents has
been elucidated and available treatments have increased substantially over the past …

Genome sequencing has become a powerful tool for studying emerging infectious diseases;
however, genome sequencing directly from clinical samples (ie, without isolation and …

Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV)
genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N …

Metagenomic sequencing has the potential to transform microbial detection and
characterization, but new tools are needed to improve its sensitivity. Here we present …

The advent of direct-acting antivirals (DAAs) has brought about a sudden renaissance in the
treatment of chronic hepatitis C virus (HCV) infection with SVR rates now routinely> 90 …

Frontiers | Hybrid Capture-Based Next Generation Sequencing and Its Application to Human
Infectious Diseases Skip to main content Top bar navigation Frontiers in Microbiology About us …

Advancing interventions to tackle the huge global burden of hepatitis B virus (HBV) infection
depends on improved insights into virus epidemiology, transmission, within-host diversity …

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host
genetic factors. Here we use human genome-wide genotyping arrays and new whole …

Viral genetic sequencing can be used to monitor the spread of HIV drug resistance, identify
appropriate antiretroviral regimes, and characterize transmission dynamics. Despite …