Oximes and hydrazones in bioconjugation: mechanism and catalysis
DK Kölmel, ET Kool - Chemical reviews, 2017 - ACS Publications
The formation of oximes and hydrazones is employed in numerous scientific fields as a
simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as …
simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as …
A not-so-ancient grease history: click chemistry and protein lipid modifications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
Quantitative profiling of protein carbonylations in ferroptosis by an aniline-derived probe
Ferroptosis is a regulated form of necrotic cell death implicated in carcinogenesis and
neurodegeneration that is driven by phospholipid peroxidation. Lipid-derived electrophiles …
neurodegeneration that is driven by phospholipid peroxidation. Lipid-derived electrophiles …
p‐Phenylenediamine‐Bridged Binder‐Electrolyte‐Unified Supramolecules for Versatile Lithium Secondary Batteries
MG Nam, J Moon, M Kim, JK Koo, JW Ho… - Advanced …, 2024 - Wiley Online Library
The binder is an essential component in determining the structural integrity and ionic
conductivity of Li‐ion battery electrodes. However, conventional binders are not sufficiently …
conductivity of Li‐ion battery electrodes. However, conventional binders are not sufficiently …
Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads
A Kumar, K Kinneer, L Masterson, E Ezeadi… - Bioorganic & medicinal …, 2018 - Elsevier
Codelivery of multiple therapeutic agents with different anticancer mechanisms can
overcome drug resistance as well as generate additive or synergistic anticancer effects that …
overcome drug resistance as well as generate additive or synergistic anticancer effects that …
Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions
Y Zhou, I Piergentili, J Hong, MP van der Helm… - Organic …, 2020 - ACS Publications
Acylhydrazones formation has been widely applied in materials science and biolabeling.
However, their sluggish condensation rate under neutral conditions limits its application …
However, their sluggish condensation rate under neutral conditions limits its application …
Simultaneous site-specific dual protein labeling using protein prenyltransferases
Site-specific protein labeling is an important technique in protein chemistry and is used for
diverse applications ranging from creating protein conjugates to protein immobilization …
diverse applications ranging from creating protein conjugates to protein immobilization …
pH-Responsive benzaldehyde-functionalized PEG-based polymeric nanoparticles for drug delivery: Effect of preparation method on morphology, dye encapsulation …
P Smyth, TJ Gibson, G Irvine, G Black, D Lavery… - European Polymer …, 2020 - Elsevier
Functionalized, pH-responsive and biocompatible polymeric nanoparticles have attracted
the interest of many researchers working on novel pharmaceutical formulations. Here, in an …
the interest of many researchers working on novel pharmaceutical formulations. Here, in an …
[HTML][HTML] Oxime blot: A novel method for reliable and sensitive detection of carbonylated proteins in diverse biological systems
Oxidative stress and oxidative protein damage occur in various biological processes and
diseases. The carbonyl group on amino acid side chains is the most widely used protein …
diseases. The carbonyl group on amino acid side chains is the most widely used protein …
Rapid and reversible hydrazone bioconjugation in cells without the use of extraneous catalysts
The amenability of hydrazone linkages to disassemble via either hydrolysis in mildly acidic
aqueous solutions or transimination upon treatment with amine nucleophiles renders them …
aqueous solutions or transimination upon treatment with amine nucleophiles renders them …