Oximes and hydrazones in bioconjugation: mechanism and catalysis

DK Kölmel, ET Kool - Chemical reviews, 2017 - ACS Publications
The formation of oximes and hydrazones is employed in numerous scientific fields as a
simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as …

A not-so-ancient grease history: click chemistry and protein lipid modifications

KF Suazo, KY Park, MD Distefano - Chemical reviews, 2021 - ACS Publications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Quantitative profiling of protein carbonylations in ferroptosis by an aniline-derived probe

Y Chen, Y Liu, T Lan, W Qin, Y Zhu, K Qin… - Journal of the …, 2018 - ACS Publications
Ferroptosis is a regulated form of necrotic cell death implicated in carcinogenesis and
neurodegeneration that is driven by phospholipid peroxidation. Lipid-derived electrophiles …

p‐Phenylenediamine‐Bridged Binder‐Electrolyte‐Unified Supramolecules for Versatile Lithium Secondary Batteries

MG Nam, J Moon, M Kim, JK Koo, JW Ho… - Advanced …, 2024 - Wiley Online Library
The binder is an essential component in determining the structural integrity and ionic
conductivity of Li‐ion battery electrodes. However, conventional binders are not sufficiently …

Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads

A Kumar, K Kinneer, L Masterson, E Ezeadi… - Bioorganic & medicinal …, 2018 - Elsevier
Codelivery of multiple therapeutic agents with different anticancer mechanisms can
overcome drug resistance as well as generate additive or synergistic anticancer effects that …

Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions

Y Zhou, I Piergentili, J Hong, MP van der Helm… - Organic …, 2020 - ACS Publications
Acylhydrazones formation has been widely applied in materials science and biolabeling.
However, their sluggish condensation rate under neutral conditions limits its application …

Simultaneous site-specific dual protein labeling using protein prenyltransferases

Y Zhang, MJ Blanden, C Sudheer… - Bioconjugate …, 2015 - ACS Publications
Site-specific protein labeling is an important technique in protein chemistry and is used for
diverse applications ranging from creating protein conjugates to protein immobilization …

pH-Responsive benzaldehyde-functionalized PEG-based polymeric nanoparticles for drug delivery: Effect of preparation method on morphology, dye encapsulation …

P Smyth, TJ Gibson, G Irvine, G Black, D Lavery… - European Polymer …, 2020 - Elsevier
Functionalized, pH-responsive and biocompatible polymeric nanoparticles have attracted
the interest of many researchers working on novel pharmaceutical formulations. Here, in an …

[HTML][HTML] Oxime blot: A novel method for reliable and sensitive detection of carbonylated proteins in diverse biological systems

R Ladouce, GF Combes, K Trajković, ID Hofman… - Redox Biology, 2023 - Elsevier
Oxidative stress and oxidative protein damage occur in various biological processes and
diseases. The carbonyl group on amino acid side chains is the most widely used protein …

Rapid and reversible hydrazone bioconjugation in cells without the use of extraneous catalysts

R Nisal, GP Jose, C Shanbhag, J Kalia - Organic & Biomolecular …, 2018 - pubs.rsc.org
The amenability of hydrazone linkages to disassemble via either hydrolysis in mildly acidic
aqueous solutions or transimination upon treatment with amine nucleophiles renders them …