Low-grade inflammation as a predictor of antidepressant and anti-inflammatory therapy response in MDD patients: a systematic review of the literature in combination …

G Arteaga-Henríquez, MS Simon, B Burger… - Frontiers in …, 2019 - frontiersin.org
Low-grade inflammation plays a role not only in the pathogenesis of major depressive
disorder (MDD) but probably also in the poor responsiveness to regular antidepressants …

Role of nitric oxide after brain ischaemia

MA Moro, A Cardenas, O Hurtado, JC Leza, I Lizasoain - Cell calcium, 2004 - Elsevier
Ischaemic stroke is the second or third leading cause of death in developed countries. In the
last two decades substantial research and efforts have been made to understand the …

Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target

M Castellanos, J Castillo, MM García, R Leira, J Serena… - Stroke, 2002 - Am Heart Assoc
Background and Purpose—The mechanisms underlying neurological deterioration in
patients with lacunar infarction are not completely understood. In this study, we sought to …

Muscle-derived autologous mitochondrial transplantation: a novel strategy for treating cerebral ischemic injury

Z Zhang, Z Ma, C Yan, K Pu, M Wu, J Bai, Y Li… - Behavioural brain …, 2019 - Elsevier
The available evidence showed that mitochondrial transfer by releasing the extracellular
vesicles containing mitochondria from astrocytes to neurons exerted a neuroprotective effect …

Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments

A Del Bene, V Palumbo, M Lamassa… - … Journal of Stroke, 2012 - journals.sagepub.com
Lacunar stroke is generally considered to have a fair outcome. However 20–30% of patients
with lacunar stroke worsen neurologically in hours or days after onset, reaching eventually …

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport

O Hurtado, MA Moro, A Cárdenas, V Sánchez… - Neurobiology of …, 2005 - Elsevier
BACKGROUND AND PURPOSE:: Cytidine-5′-diphosphocholine (citicoline or CDP-
choline), an intermediate in the biosynthesis of phosphatidylcholine, has shown beneficial …

Mitochondrial respiratory chain and free radical generation in stroke

MA Moro, A Almeida, JP Bolaños, I Lizasoain - Free Radical Biology and …, 2005 - Elsevier
Being the second most common cause of death in the industrial countries and one of the
major causes of death and disability, stroke has a great effect on public health and is the …

Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: therapeutic implications

JP Bolaños, MA Moro, I Lizasoain, A Almeida - Advanced drug delivery …, 2009 - Elsevier
Mitochondria represent both the main source and target of reactive oxygen and nitrogen
species (RONS). In view of the large energy expenditure made by neurons during …

Neuroprotective effects of hydroxysafflor yellow A: in vivo and in vitro studies

H Zhu, Z Wang, C Ma, J Tian, F Fu, C Li, D Guo… - Planta …, 2003 - thieme-connect.com
Previous work has shown that hydroxysafflor yellow A (HSYA), extracted from Carthamus
tinctorius L. markedly extended the coagulation time in mice and exhibited a significant …

Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain

JLM Madrigal, MA Moro, I Lizasoain… - …, 2003 - nature.com
Cyclooxygenase (COX) is the rate-limiting enzyme in the metabolism of arachidonic acid
into prostanoids. Although it is constitutively expressed in brain neurons, the inducible …