Several editions of the World Health Organization (WHO) classifications of lympho-
hemopoietic neoplasms in 2001, 2008 and 2017 served as the international standard for …

Hairy cell leukemia is an uncommon hematologic malignancy characterized by
pancytopenia and marked susceptibility to infection. Tremendous progress in the …

Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and
clonal evolution. The molecular profile of CRC is routinely assessed in surgical or bioptic …

Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic
leukemia (CLL). The acquisition and selection of genomic aberrations may be critical to …

Background BRAF V600E is the genetic lesion underlying hairy-cell leukemia. We assessed
the safety and activity of the oral BRAF inhibitor vemurafenib in patients with hairy-cell …

TP53 mutations are strong predictors of poor survival and refractoriness in chronic
lymphocytic leukemia (CLL) and have direct implications for disease management. Clinical …

Background Hairy-cell leukemia (HCL) is a CD20+ indolent B-cell cancer in which a BRAF
V600E kinase–activating mutation plays a pathogenetic role. In clinical trials involving …

A study has shown that MYD88 (L265P) is a recurring somatic mutation in Waldenström's
macroglobulinemia (WM). We developed an allele-specific polymerase chain reaction …

To understand the genetic mechanisms driving variant and IGHV4-34–expressing hairy-cell
leukemias, we performed whole-exome sequencing of leukemia samples from ten affected …

Splenic marginal zone lymphoma (SMZL) is a B cell malignancy of unknown pathogenesis,
and thus an orphan of targeted therapies. By integrating whole-exome sequencing and copy …