Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known
roles have extended from within the immune system to include a neuro-inflammatory domain …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

The first point of our body's contact with tactile stimuli (innocuous and noxious) is the
epidermis, the outermost layer of skin that is largely composed of keratinocytes. Here, we …

P2X3 and P2X2/3 receptors are highly localized on peripheral and central processes of
sensory afferent nerves, and activation of these channels contributes to the pronociceptive …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

In the central nervous system (CNS), adenosine is an important neuromodulator and
regulates neuronal and non-neuronal cellular function (eg microglia) by actions on …

Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the
peripheral activation of primary sensory afferent neurons. The localized peripheral …