Protein–protein interactions are fundamental to various aspects of cell biology with many
protein complexes participating in numerous fundamental biological processes such as …

There is a critical need for the discovery of novel biomarkers for early detection and targeted
therapy of cancer, a major cause of deaths worldwide. In this respect, proteomic …

The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility
and fertilization via HCO3−-stimulated cAMP synthesis. A complex network of signaling …

Regulation of protein turnover allows cells to react to their environment and maintain
homeostasis. Proteins can show different turnover rates in different tissue, but little is known …

The pyruvate dehydrogenase complex (PDHc) is a giant enzymatic assembly involved in
pyruvate oxidation. PDHc components have been characterized in isolation, but the …

The characterization of biotherapeutics represents a major analytical challenge. This review
discusses the current state‐of‐the‐art in analytical technologies to profile biopharma …

Studying protein-protein interaction networks provide key evidence for the underlying
molecular mechanisms. Mass spectrometry-based proteomic approaches have been …

The development of rapid, sensitive, and accurate mass spectrometric methods for
measuring peptides, proteins, and even intact protein assemblies has made mass …

Background As a comprehensive discipline that studies food and nutrition, foodomics
requires reliable qualitative and quantitative information about the food proteome …

The proteasome controls a multitude of cellular processes through protein degradation and
has been identified as a therapeutic target in oncology. However, our understanding of its …