The incidence of hyperuricemia (HUA) and gout continuously increases and has become a
major public health problem. The gut microbiota, which colonizes the human intestine, has a …

Numerous studies have demonstrated that gut microbiota is essential for the host's health
because it regulates the host's metabolism, endocrine, and immune systems. In recent …

Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular
mechanisms and no disease-modifying drugs. In this study, we performed single-cell RNA …

Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the
effect of the microbiome on uric acid (UA) metabolism remains unclear. This study aimed to …

Hyperuricemia with consequent monosodium urate crystal deposition leads to gout,
characterized by painful, incapacitating inflammatory arthritis flares that are also associated …

Hyperuricemia induces inflammatory arthritis and accelerates the progression of renal and
cardiovascular diseases. Gut microbiota has been linked to the development of …

Uric acid is the final product of purine metabolism and is converted to allantoin in most
mammals via the uricase enzyme. The accumulation of loss of function mutations in the …

Abstract Beta-glucan (BG), a polysaccharide comprised of interfacing glucose monomers
joined via beta-glycosidic linkages, can be defined as a type of dietary fiber with high …

Purpose The goal of this study was to examine the role of sodium butyrate in preserving the
intestinal mucosal barrier and reducing hyperuricemia (HUA). Methods First, we established …

Obesity is a risk factor for the development of hyperuricemia, both of which were related to
gut microbiota. However, whether alterations in the gut microbiota lie in the pathways …