Pharmacokinetics and pharmacodynamics in clinical use of scopolamine
UD Renner, R Oertel, W Kirch - Therapeutic drug monitoring, 2005 - journals.lww.com
Abstract The alkaloid L-(−)-scopolamine [L-(−)-hyoscine] competitively inhibits muscarinic
receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both …
receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both …
Neuropharmacology of vestibular system disorders
This work reviews the neuropharmacology of the vestibular system, with an emphasis on the
mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists …
mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists …
Transdermal scopolamine for prevention of motion sickness: clinical pharmacokinetics and therapeutic applications
Z Nachum, A Shupak, CR Gordon - Clinical pharmacokinetics, 2006 - Springer
A transdermal therapeutic system for scopolamine (TTS-S) was developed to counter the
adverse effects and short duration of action that has restricted the usefulness of scopolamine …
adverse effects and short duration of action that has restricted the usefulness of scopolamine …
M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle
KM Hurley, S Gaboyard, M Zhong, SD Price… - Journal of …, 2006 - Soc Neuroscience
Type I vestibular hair cells have large K+ currents that, like neuronal M currents, activate
negative to resting potential and are modulatable. In rodents, these currents are acquired …
negative to resting potential and are modulatable. In rodents, these currents are acquired …
Neurochemical mechanisms and pharmacologic strategies in managing nausea and vomiting related to cyclic vomiting syndrome and other gastrointestinal disorders
M Bashashati, RW McCallum - European journal of pharmacology, 2014 - Elsevier
Nausea and vomiting are common gastrointestinal complaints which could be triggered by
stimuli in both the peripheral and central nervous systems. They may be considered as …
stimuli in both the peripheral and central nervous systems. They may be considered as …
The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents
Electrical stimulation of the mammalian efferent vestibular system (EVS) predominantly
excites primary vestibular afferents along two distinct time scales. Although roles for …
excites primary vestibular afferents along two distinct time scales. Although roles for …
A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications
LA Poppi, JC Holt, R Lim… - Journal of …, 2020 - journals.physiology.org
It has been over 60 years since peripheral efferent vestibular terminals were first identified in
mammals, and yet the function of the efferent vestibular system remains obscure. One …
mammals, and yet the function of the efferent vestibular system remains obscure. One …
Muscarinic acetylcholine receptors and M-currents underlie efferent-mediated slow excitation in calyx-bearing vestibular afferents
JC Holt, PM Jordan, A Lysakowski, A Shah… - Journal of …, 2017 - Soc Neuroscience
Stimulation of vestibular efferent neurons excites calyx and dimorphic (CD) afferents. This
excitation consists of fast and slow components that differ> 100-fold in activation kinetics and …
excitation consists of fast and slow components that differ> 100-fold in activation kinetics and …
Channeling your inner ear potassium: K+ channels in vestibular hair cells
FL Meredith, KJ Rennie - Hearing research, 2016 - Elsevier
During development of vestibular hair cells, K+ conductances are acquired in a specific
pattern. Functionally mature vestibular hair cells express different complements of K+ …
pattern. Functionally mature vestibular hair cells express different complements of K+ …
Neuropharmacological basis of vestibular system disorder treatment
This work reviews the neuropharmacology of the vestibular system, with an emphasis on the
mechanism of action of drugs used in the treatment of vestibular disorders. Clinicians are …
mechanism of action of drugs used in the treatment of vestibular disorders. Clinicians are …