Pharmacokinetics and pharmacodynamics in clinical use of scopolamine

UD Renner, R Oertel, W Kirch - Therapeutic drug monitoring, 2005 - journals.lww.com
Abstract The alkaloid L-(−)-scopolamine [L-(−)-hyoscine] competitively inhibits muscarinic
receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both …

Neuropharmacology of vestibular system disorders

E Soto, R Vega - Current Neuropharmacology, 2010 - ingentaconnect.com
This work reviews the neuropharmacology of the vestibular system, with an emphasis on the
mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists …

Transdermal scopolamine for prevention of motion sickness: clinical pharmacokinetics and therapeutic applications

Z Nachum, A Shupak, CR Gordon - Clinical pharmacokinetics, 2006 - Springer
A transdermal therapeutic system for scopolamine (TTS-S) was developed to counter the
adverse effects and short duration of action that has restricted the usefulness of scopolamine …

M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle

KM Hurley, S Gaboyard, M Zhong, SD Price… - Journal of …, 2006 - Soc Neuroscience
Type I vestibular hair cells have large K+ currents that, like neuronal M currents, activate
negative to resting potential and are modulatable. In rodents, these currents are acquired …

Neurochemical mechanisms and pharmacologic strategies in managing nausea and vomiting related to cyclic vomiting syndrome and other gastrointestinal disorders

M Bashashati, RW McCallum - European journal of pharmacology, 2014 - Elsevier
Nausea and vomiting are common gastrointestinal complaints which could be triggered by
stimuli in both the peripheral and central nervous systems. They may be considered as …

The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents

GT Schneider, C Lee, AK Sinha, PM Jordan, JC Holt - Scientific Reports, 2021 - nature.com
Electrical stimulation of the mammalian efferent vestibular system (EVS) predominantly
excites primary vestibular afferents along two distinct time scales. Although roles for …

A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications

LA Poppi, JC Holt, R Lim… - Journal of …, 2020 - journals.physiology.org
It has been over 60 years since peripheral efferent vestibular terminals were first identified in
mammals, and yet the function of the efferent vestibular system remains obscure. One …

Muscarinic acetylcholine receptors and M-currents underlie efferent-mediated slow excitation in calyx-bearing vestibular afferents

JC Holt, PM Jordan, A Lysakowski, A Shah… - Journal of …, 2017 - Soc Neuroscience
Stimulation of vestibular efferent neurons excites calyx and dimorphic (CD) afferents. This
excitation consists of fast and slow components that differ> 100-fold in activation kinetics and …

Channeling your inner ear potassium: K+ channels in vestibular hair cells

FL Meredith, KJ Rennie - Hearing research, 2016 - Elsevier
During development of vestibular hair cells, K+ conductances are acquired in a specific
pattern. Functionally mature vestibular hair cells express different complements of K+ …

Neuropharmacological basis of vestibular system disorder treatment

E Soto, R Vega, E Seseña - Journal of Vestibular Research, 2013 - content.iospress.com
This work reviews the neuropharmacology of the vestibular system, with an emphasis on the
mechanism of action of drugs used in the treatment of vestibular disorders. Clinicians are …