DNA oxidation and excision repair pathways
The physiological impact of the aberrant oxidation products on genomic DNA were
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …
On the relevance of hydroxyl radical to purine DNA damage
Hydroxyl radical (HO•) is the most reactive toward DNA among the reactive oxygen species
(ROS) generated in aerobic organisms by cellular metabolisms. HO• is generated also by …
(ROS) generated in aerobic organisms by cellular metabolisms. HO• is generated also by …
Chemical analysis of DNA damage
In human cells, the integrity of genetic information is constantly challenged by endogenous
and exogenous chemical agents that can induce DNA damage. To counteract the …
and exogenous chemical agents that can induce DNA damage. To counteract the …
Metabolomics profiling reveals defense strategies of Pediococcus pentosaceus R1 isolated from Harbin dry sausages under oxidative stress
H Zhang, J Liu, R Wen, Q Chen, B Kong - LWT, 2021 - Elsevier
The physiological performance and whole-cell metabolomic response of Pediococcus
pentosaceus R1 to oxidative stress were investigated. The response to a sublethal …
pentosaceus R1 to oxidative stress were investigated. The response to a sublethal …
Radical Reactions in Organic Synthesis: Exploring in-, on-, and with-Water Methods
C Chatgilialoglu, S Barata-Vallejo, T Gimisis - Molecules, 2024 - mdpi.com
Radical reactions in water or aqueous media are important for organic synthesis, realizing
high-yielding processes under non-toxic and environmentally friendly conditions. This …
high-yielding processes under non-toxic and environmentally friendly conditions. This …
5′, 8-Cyclopurine lesions in DNA damage: Chemical, analytical, biological, and diagnostic significance
Purine 5′, 8-cyclo-2′-deoxynucleosides (cPu) are tandem-type lesions observed among
the DNA purine modifications and identified in mammalian cellular DNA in vivo. These …
the DNA purine modifications and identified in mammalian cellular DNA in vivo. These …
Oxygen-dependent accumulation of purine DNA lesions in Cockayne Syndrome cells
Cockayne Syndrome (CS) is an autosomal recessive neurodegenerative premature aging
disorder associated with defects in nucleotide excision repair (NER). Cells from CS patients …
disorder associated with defects in nucleotide excision repair (NER). Cells from CS patients …
Oxygen dependent purine lesions in double-stranded oligodeoxynucleotides: Kinetic and computational studies highlight the mechanism for 5′, 8-cyclopurine …
The reaction of HO• radical with DNA is intensively studied both mechanistically and
analytically for lesions formation. Several aspects related to the reaction paths of purine …
analytically for lesions formation. Several aspects related to the reaction paths of purine …
[HTML][HTML] High levels of oxidatively generated DNA damage 8, 5′-cyclo-2′-deoxyadenosine accumulate in the brain tissues of xeroderma pigmentosum group A …
T Mori, H Nakane, T Iwamoto, MG Krokidis… - DNA repair, 2019 - Elsevier
Xeroderma pigmentosum (XP) is a genetic disorder associated with defects in nucleotide
excision repair, a pathway that eliminates a wide variety of helix-distorting DNA lesions …
excision repair, a pathway that eliminates a wide variety of helix-distorting DNA lesions …
New insights into the reaction paths of hydroxyl radicals with purine moieties in DNA and double-stranded oligodeoxynucleotides
The reaction of hydroxyl radical (HO•) with DNA produces many primary reactive species
and many lesions as final products. In this study, we have examined the optical spectra of …
and many lesions as final products. In this study, we have examined the optical spectra of …