Recent advances in the development of therapeutic peptides

J Fetse, S Kandel, UF Mamani, K Cheng - Trends in Pharmacological …, 2023 - cell.com
Peptides have unique characteristics that make them highly desirable as therapeutic agents.
The physicochemical and proteolytic stability profiles determine the therapeutic potential of …

Neurolysin Knockout Mice in a Diet-Induced Obesity Model

B Caprioli, RAS Eichler, RNO Silva, LF Martucci… - International Journal of …, 2023 - mdpi.com
Neurolysin oligopeptidase (EC 3.4. 24.16; Nln), a member of the zinc metallopeptidase M3
family, was first identified in rat brain synaptic membranes hydrolyzing neurotensin at the …

Lipid-lowering effect of microencapsulated peptides from brewer's spent grain in high-sucrose diet-fed rats

MR Ferreira, AG Garzón, ME Oliva, RE Cian, SR Drago… - Food Bioscience, 2022 - Elsevier
Brewer's spent grain (BSG)-a byproduct generated from the processing of beer-brewing
industry-is currently recognized as an important source of bioactive peptides with potential …

Peptidomic profiling of cerebrospinal fluid from patients with intracranial saccular aneurysms

GR Sakaya, CA Parada, RA Eichler, VN Yamaki… - Journal of …, 2021 - Elsevier
Intracranial saccular aneurysms (ISA) represent 90%–95% of all intracranial aneurysm
cases, characterizing abnormal pockets at arterial branch points. Ruptures lead to …

Revealing Natural Intracellular Peptides in Gills of Seahorse Hippocampus reidi

CN Correa, LO Fiametti, GM de Barros, LM de Castro - Biomolecules, 2023 - mdpi.com
The seahorse is a marine teleost fish member of the Syngnathidae family that displays a
complex variety of morphological and reproductive behavior innovations and has been …

Intracellular peptides as drug prototypes

MCF Gewehr, A Navon, ES Ferro - Peptide and Peptidomimetic …, 2022 - Elsevier
Proteasome-processed functional intracellular peptides (InPeps) were recently described,
suggesting the need for adapting our understanding of how cells build macromolecular …

[PDF][PDF] Sample preparation and relative quantitation using reductive methylation of amines for Peptidomics studies

CN Correa, LO Fiametti, MEM Esquinca… - JoVE (Journal of …, 2021 - drive.google.com
Peptidomics can be defined as the qualitative and quantitative analysis of peptides in a
biological sample. Its main applications include identifying the peptide biomarkers of …

Análise das alterações fenotípicas e metabólicas de animais com deleção do gene da neurolisina (EC 3.4. 24.16), em modelo de obesidade induzida por dieta.

B Caprioli - 2023 - teses.usp.br
A endo-oligopeptidase neurolisina (EC 3.4. 24.16; Nln) foi primeiro identificada em
membranas sinápticas de cérebro de ratos, como uma peptidase com habilidade para …

[PDF][PDF] ФАРМАКОЛОГИЧЕСКИЕ ЭФФЕКТЫ ТЕХНОЛОГИЧЕСКИ ОБРАБОТАННЫХ АНТИТЕЛ К ЭНДОГЕННЫМ МОЛЕКУЛАМ (экспериментально-клиническое …

СА ТАРАСОВ - tnimc.ru
Актуальность темы исследования. Идеальное лекарственное средство должно
обладать максимальной селективностью к своей мишени в организме человека в …

Bioactive Peptides Derived from Cereals and Their Health Potential

M Miraghajani, AV Lazaridi, H Hajianfar - Bioactive Peptides, 2021 - taylorfrancis.com
Nowadays, proteins are not only considered a source of essential amino acids and nitrogen
but also physiochemical active compounds that provide health benefits and inhibit the …