[HTML][HTML] Silent agonists for α7 nicotinic acetylcholine receptors
RL Papke, M Quadri, A Gulsevin - Pharmacological Research, 2023 - Elsevier
We discuss models for the activation and desensitization of α7 nicotinic acetylcholine
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …
Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation
The cholinergic anti-inflammatory reflex (CAIR) represents an important homeostatic
regulatory mechanism for sensing and controlling the body's response to inflammatory …
regulatory mechanism for sensing and controlling the body's response to inflammatory …
Stable desensitization of α7 nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site
MC Pismataro, NA Horenstein, C Stokes… - European journal of …, 2021 - Elsevier
NS6740 is an α 7 nicotinic acetylcholine receptor-selective partial agonist with low efficacy
for channel activation, capable of promoting the stable conversion of the receptors to …
for channel activation, capable of promoting the stable conversion of the receptors to …
Identification of the Secondary Metabolites of Sargassum Tenerrimum and their Molecular Docking Analysis against the Targets of Anxiety, Depression and Cognitive …
R Yadav, P Kumaravelu… - Letters in Drug …, 2024 - benthamdirect.com
Objective: This article aimed to identify the bioactive compounds present in the brown algae
Sargassum tenerrimum using TLC and HPTLC fingerprinting analysis and followed in silico …
Sargassum tenerrimum using TLC and HPTLC fingerprinting analysis and followed in silico …
Synthesis and characterization of αM-conotoxin SIIID, a reversible human α7 nicotinic acetylcholine receptor antagonist
H Wang, Y Li, M Yang, M Zhou - Toxicon, 2022 - Elsevier
Abstract α-Conotoxins, a group of small marine peptide toxins that target nAChRs with high
potency and selectivity, are valuable pharmacological tools and potential drug leads. In this …
potency and selectivity, are valuable pharmacological tools and potential drug leads. In this …
Diseño, síntesis y evaluación farmacológica de nuevos fármacos multidiana para el tratamiento de la enfermedad de Alzheimer
E Crisman Vigil - 2024 - docta.ucm.es
Diseño, síntesis y evaluación farmacológica de nuevos fármacos multidiana para el
tratamiento de la enfermedad de Alzheimer Page 1 UNIVERSIDAD COMPLUTENSE DE …
tratamiento de la enfermedad de Alzheimer Page 1 UNIVERSIDAD COMPLUTENSE DE …
Exploring the role of CHRFAM7A in the early stages of Alzheimer's disease: in vitro studies and development of a novel humanized mouse model
ML Pou - 2023 - theses.hal.science
CHRFAM7A is a human-specific gene that encodes the nicotinic acetylcholine receptor
(nAChR) subunit dupα7. This gene originated after a fusion between a partial duplication of …
(nAChR) subunit dupα7. This gene originated after a fusion between a partial duplication of …
Interdisciplinary study of the antidepressant effect of dexmecamylamine: a meta-analysis and computational study
Y Yang - 2023 - ses.library.usyd.edu.au
Nicotinic acetylcholine receptors (nAChRs) are widespread ligand-gated ion channels in the
human brain, playing crucial roles in various physiological processes such as hormone …
human brain, playing crucial roles in various physiological processes such as hormone …
A computational analysis of the factors governing the dynamics of α7 nAChR and its homologs
A Gulsevin, J Meiler, NA Horenstein - Biophysical Journal, 2020 - cell.com
The α7 nicotinic acetylcholine receptor is a homopentameric ion channel from the Cys-loop
receptor superfamily targeted for psychiatric indications and inflammatory pain. Molecular …
receptor superfamily targeted for psychiatric indications and inflammatory pain. Molecular …