piRNA-guided genome defense: from biogenesis to silencing
PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
[HTML][HTML] One loop to rule them all: the ping-pong cycle and piRNA-guided silencing
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …
the genetic information of animal germ cells from the deleterious effects of molecular …
The Release 6 reference sequence of the Drosophila melanogaster genome
RA Hoskins, JW Carlson, KH Wan, S Park… - Genome …, 2015 - genome.cshlp.org
Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies
of heredity, development, metabolism, behavior, and human disease. The initial reference …
of heredity, development, metabolism, behavior, and human disease. The initial reference …
Small silencing RNAs: an expanding universe
M Ghildiyal, PD Zamore - Nature reviews genetics, 2009 - nature.com
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA
classes have been identified, including microRNAs (miRNAs), small interfering RNAs …
classes have been identified, including microRNAs (miRNAs), small interfering RNAs …
[HTML][HTML] Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
Drosophila Piwi-family proteins have been implicated in transposon control. Here, we
examine piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and …
examine piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and …
Dynamic interactions between transposable elements and their hosts
Transposable elements (TEs) have a unique ability to mobilize to new genomic locations,
and the major advance of second-generation DNA sequencing has provided insights into …
and the major advance of second-generation DNA sequencing has provided insights into …
[HTML][HTML] Epigenetic reprogramming and small RNA silencing of transposable elements in pollen
The mutagenic activity of transposable elements (TEs) is suppressed by epigenetic silencing
and small interfering RNAs (siRNAs), especially in gametes that could transmit transposed …
and small interfering RNAs (siRNAs), especially in gametes that could transmit transposed …
[HTML][HTML] Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation
PIWI proteins and their guiding Piwi-interacting small RNAs (piRNAs) are crucial for fertility
and transposon defense in the animal germline. In most species, the majority of piRNAs are …
and transposon defense in the animal germline. In most species, the majority of piRNAs are …
[HTML][HTML] Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies
Piwi-interacting RNAs (piRNAs) silence transposons in animal germ cells. piRNAs are
thought to derive from long transcripts spanning transposon-rich genomic loci and to direct …
thought to derive from long transcripts spanning transposon-rich genomic loci and to direct …