The role of matrix metalloproteinases in the epithelial‐mesenchymal transition of hepatocellular carcinoma

C Scheau, IA Badarau, R Costache… - Analytical cellular …, 2019 - Wiley Online Library
The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …

[HTML][HTML] Apolipoprotein AI (ApoA-I), immunity, inflammation and cancer

K Georgila, D Vyrla, E Drakos - Cancers, 2019 - mdpi.com
Apolipoprotein AI (ApoA-I), the major protein component of high-density lipoproteins (HDL)
is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune …

[HTML][HTML] HDL and cancer-causality still needs to be confirmed? Update 2020

S Ganjali, M Banach, M Pirro, Z Fras… - Seminars in cancer …, 2021 - Elsevier
An inverse correlation between high-density lipoprotein cholesterol (HDL-C) and cancer risk
has been shown by several epidemiological studies. Some studies have even suggested …

[HTML][HTML] Proteomics-based identification of dysregulated proteins in breast cancer

AN Neagu, M Jayathirtha, D Whitham, P Mutsengi… - Proteomes, 2022 - mdpi.com
Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

[HTML][HTML] Proteomics-Based identification of dysregulated proteins and biomarker discovery in invasive ductal carcinoma, the most common breast cancer subtype

AN Neagu, D Whitham, L Seymour, N Haaker, I Pelkey… - Proteomes, 2023 - mdpi.com
Invasive ductal carcinoma (IDC) is the most common histological subtype of malignant
breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great …

[HTML][HTML] Proteomics of muscle microdialysates identifies potential circulating biomarkers in facioscapulohumeral muscular dystrophy

V Corasolla Carregari, M Monforte, G Di Maio… - International journal of …, 2020 - mdpi.com
Facioscapulohumeral muscular dystrophy (FSHD) is caused by a complex epigenetic
mechanism finally leading to the misexpression of DUX4 in skeletal muscle. Detecting DUX4 …

[HTML][HTML] Apolipoproteins: New players in cancers

Y He, J Chen, Y Ma, H Chen - Frontiers in Pharmacology, 2022 - frontiersin.org
Apolipoproteins (APOs), the primary protein moiety of lipoproteins, are known for their
crucial role in lipid traffic and metabolism. Despite extensive exploration of APOs in …

CDC7 as a novel biomarker and druggable target in cancer

R Liu, Y Huang - Clinical and Translational Oncology, 2022 - Springer
Due to the bottlenecks encountered in traditional treatment for tumor, more effective drug
targets need to be developed. Cell division cycle 7 kinase plays an important role in DNA …

Deciphering a proteomic signature for the early detection of breast cancer from breast milk: the role of quantitative proteomics

D Whitham, P Bruno, N Haaker, KF Arcaro… - Expert Review of …, 2024 - Taylor & Francis
Introduction Breast cancer is one of the most prevalent cancers among women in the United
States. Current research regarding breast milk has been focused on the composition and its …

[HTML][HTML] Aberrant super-enhancer-driven oncogene ENC1 promotes the radio-resistance of breast carcinoma

L Li, N Wang, M Zhu, Y Xiong, F Wang, G Guo… - Cell Death & …, 2021 - nature.com
Poor response of tumors to radiotherapy is a major clinical obstacle. Because of the dynamic
characteristics of the epigenome, identification of possible epigenetic modifiers may be …