Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a progressive, fatal, inherited
disorder first identified in Portugal and now recognized in all continents. Over the past …

Amyloidoses represent a group of diseases characterized by the pathological accumulation
in the extracellular area of insoluble misfolded protein material called “amyloid”. The …

The liver‐derived, circulating transport protein transthyretin (TTR) is the cause of systemic
hereditary (ATTRv) and wild‐type (ATTRwt) amyloidosis. TTR stabilization and knockdown …

The past few years have witnessed an unprecedented acceleration in the clinical
development of novel therapeutic options for hereditary transthyretin amyloidosis. Recently …

Hereditary transthyretin (TTR) amyloidosis (hATTR) is a rare life-threatening disorder
caused by amyloidogenic coding mutations located in TTR gene. To understand the high …

Transthyretin (TTR) gene has a causal role in a hereditary form of amyloidosis (ATTRm) and
is potentially involved in the risk of wild-type transthyretin amyloidosis (ATTRwt). To …

Transthyretin (TTR), a homotetrameric protein found in plasma, cerebrospinal fluid, and the
eye, plays a pivotal role in the onset of several amyloid diseases with high morbidity and …

Hereditary transthyretin amyloidosis (hATTR) with polyneuropathy (formerly known as
Familial Amyloid Polyneuropathy (FAP)) is an endemic amyloidosis involving the harmful …

Hereditary transthyretin-related amyloidosis (ATTRv amyloidosis) is a rare and progressively
debilitating disease characterized by the deposition of transthyretin (TTR) amyloid fibrils in …

Infiltrative cardiomyopathies are characterized by abnormal deposition or accumulation of
substances in the heart. Essentially, these diseases have similarities and overlaps in …