Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on
the surface of the brain. Historically considered a result of head trauma, recent evidence …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Abstract Purpose: Testing safety of Delta24-RGD (DNX-2401), an oncolytic adenovirus,
locally delivered by convection enhanced delivery (CED) in tumor and surrounding brain of …

Neurotransmitters, as important chemical small molecules, perform the function of neural
signal transmission from cell to cell. Excess concentrations of neurotransmitters are often …

Epileptic seizures are a common and poorly understood comorbidity for individuals with
primary brain tumors. To investigate peritumoral seizure etiology, we implanted human …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Glioma is the most common malignant primary brain tumor. Its rapid growth is aided by
tumor-mediated glutamate release, creating peritumoral excitotoxic cell death and vacating …

Epilepsy often develops in patients with glioma, and the two conditions share common
pathogenic mechanisms. Altered expression of glutamate transporters, including the cystine …