Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an
increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the …

Despite its central importance in cellular metabolism, many details remain to be determined
regarding subcellular lactate metabolism and its regulation in physiology and disease, as …

The molecular transducers of benefits from different exercise modalities remain incompletely
defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance …

Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …

It is well established that lactate secreted by fermenting cells can be oxidized or used as a
gluconeogenic substrate by other cells and tissues. It is generally assumed, however, that …

Mitochondria are major suppliers of cellular energy through nutrients oxidation. Little is
known about the mechanisms that enable mitochondria to cope with changes in nutrient …

Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal
failure, where concentrations of the active vitamin D 3 metabolite, 1α, 25-dihydroxyvitamin D …

Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …

Background Epithelial ovarian cancer is the leading cause of gynecologic cancer deaths.
Most patients respond initially to platinum-based chemotherapy after surgical debulking …