1001 lights: luciferins, luciferases, their mechanisms of action and applications in chemical analysis, biology and medicine
ZM Kaskova, AS Tsarkova, IV Yampolsky - Chemical Society Reviews, 2016 - pubs.rsc.org
Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …
Mitochondrial dysfunction in heart failure with preserved ejection fraction
AA Kumar, DP Kelly, JA Chirinos - Circulation, 2019 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an
increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the …
increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the …
[HTML][HTML] Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease
X Li, Y Zhang, L Xu, A Wang, Y Zou, T Li, L Huang… - Cell metabolism, 2023 - cell.com
Despite its central importance in cellular metabolism, many details remain to be determined
regarding subcellular lactate metabolism and its regulation in physiology and disease, as …
regarding subcellular lactate metabolism and its regulation in physiology and disease, as …
[HTML][HTML] Enhanced protein translation underlies improved metabolic and physical adaptations to different exercise training modes in young and old humans
The molecular transducers of benefits from different exercise modalities remain incompletely
defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance …
defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance …
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity
Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …
Lactate metabolism is associated with mammalian mitochondria
YJ Chen, NG Mahieu, X Huang, M Singh… - Nature chemical …, 2016 - nature.com
It is well established that lactate secreted by fermenting cells can be oxidized or used as a
gluconeogenic substrate by other cells and tissues. It is generally assumed, however, that …
gluconeogenic substrate by other cells and tissues. It is generally assumed, however, that …
Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins
A Neufeld-Cohen, MS Robles… - Proceedings of the …, 2016 - National Acad Sciences
Mitochondria are major suppliers of cellular energy through nutrients oxidation. Little is
known about the mechanisms that enable mitochondria to cope with changes in nutrient …
known about the mechanisms that enable mitochondria to cope with changes in nutrient …
1α, 25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells
ZC Ryan, TA Craig, CD Folmes, X Wang… - Journal of Biological …, 2016 - ASBMB
Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal
failure, where concentrations of the active vitamin D 3 metabolite, 1α, 25-dihydroxyvitamin D …
failure, where concentrations of the active vitamin D 3 metabolite, 1α, 25-dihydroxyvitamin D …
Mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment
VJ Clemente-Suárez, A Martín-Rodríguez… - International Journal of …, 2023 - mdpi.com
Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance
S Bhattacharyya, S Saha, K Giri, IR Lanza, KS Nair… - PloS one, 2013 - journals.plos.org
Background Epithelial ovarian cancer is the leading cause of gynecologic cancer deaths.
Most patients respond initially to platinum-based chemotherapy after surgical debulking …
Most patients respond initially to platinum-based chemotherapy after surgical debulking …