DNA methylation (5-methylcytosine, 5-mC) is the best characterized epigenetic mark that
has regulatory roles in diverse biological processes. Recent investigation of RNA …

Epigenetic modifications are closely related to certain disorders of the organism, including
the development of tumors. One of the main epigenetic modifications is the methylation of …

Extracellular ATP has been shown to either inhibit or promote cancer growth and migration;
however, the mechanism underlying this discrepancy remained elusive. Here we …

Although the skeleton is one of the predominant sites for breast cancer metastasis, why
breast cancer cells often become dormant after homing to bone is not well understood. Here …

Enzyme kinetic analysis reveals a dynamic relationship between enzymes and their
substrates. Overall enzyme activity can be controlled by both protein expression and various …

Investigation into intracellular ribonucleotides (RNs) and deoxyribonucleotides (dRNs) is
important for studies of the mechanism of many biological processes, such as RNA and DNA …

Despite the apparent clinical benefits of high-dose cytarabine (Ara-C) over lower dose Ara-C
in acute myeloid leukemia (AML) therapy, the mechanism behind high-dose Ara-C therapy …

We hypothesized that competition between nucleotide reverse‐transcriptase inhibitor
triphosphate and endogenous deoxyribonucleotide triphosphate (dNTP) may lead to …

Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide.
Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy …

We present here a novel and highly sensitive ion-pair hydrophilic interaction
chromatography–tandem mass spectrometry (IP–HILIC–MS/MS) method for quantitation of …