Tissue-resident macrophages have pivotal functions for tissue defense and homeostasis.
Two main discoveries have changed our current understanding of macrophage …

Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …

Understanding gene regulation and function requires a genome-wide method capable of
capturing both gene expression levels and isoform diversity at the single-cell level. Short …

The perinatal period is a critical window for distribution of innate tissue-resident immune
cells within developing organs. Despite epidemiologic evidence implicating the early-life …

Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

The classical roadmap of hematopoietic hierarchy has been proposed for nearly 20 years
and has become a dogma of stem cell research for most types of adult stem cells, including …