Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

Gene expression is the fundamental level at which the results of various genetic and
regulatory programs are observable. The measurement of transcriptome-wide gene …

Trajectory inference has radically enhanced single-cell RNA-seq research by enabling the
study of dynamic changes in gene expression. Downstream of trajectory inference, it is vital …

Detection of differential transcript usage (DTU) from RNA-seq data is an important
bioinformatic analysis that complements differential gene expression analysis. Here we …

The salinity gradient separating marine and freshwater environments represents a major
ecological divide for microbiota, yet the mechanisms by which marine microbes have …

RNA sequencing studies with complex designs and transcript-resolution analyses involve
multiple hypotheses per gene; however, conventional approaches fail to control the false …

We explain the problem of selective inference in complex research using a recently
published study: a replicability study of the associations in order to reveal and establish risk …

In many complex multiple-testing problems the hypotheses are divided into families. Given
the data, families with evidence for true discoveries are selected, and hypotheses within …

Although sexual reproduction is believed to play a major role in the high diversification rates
and species richness of diatoms, a mechanistic understanding of diatom life cycle control is …

The salinity gradient separating marine and freshwater environments is a major ecological
divide, and the mechanisms by which most organisms adapt to new salinity environments …