Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Alzheimer's disease (AD), the most common form of dementia, is a progressive and
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …

Background Recent clinical and experimental studies have highlighted the involvement of
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …

What happens precociously to the brain destined to develop Alzheimer's Disease (AD) still
remains to be elucidated and this is one reason why effective AD treatments are missing …

Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental
Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre …

Purpose Alzheimer's disease (AD) is a progressive, incurable human brain illness that
impairs reasoning and retention as well as recall. Detecting AD in its preliminary stages …

Background Preclinical and pathology evidence suggests an involvement of brain dopamine
(DA) circuitry in Alzheimer's disease (AD). We in vivo investigated if, when, and in which …

A common symptom in Alzheimer's disease (AD) is cognitive decline, of which the potential
pathogenesis remains unclear. In order to understand the mechanism of gut microbiota in …

Neuropsychiatric symptoms (NPS) occur in nearly all patients with Alzheimer's Disease
(AD). Most frequently they appear since the mild cognitive impairment (MCI) stage preceding …

Gradual decline in cognitive and non-cognitive functions are considered clinical hallmarks of
Alzheimer's Disease (AD). Post-mortem autoptic analysis shows the presence of amyloid β …