The advent of ultrafast X-ray free-electron lasers (XFELs) opens the tantalizing possibility of
the atomic-resolution imaging of reproducible objects such as viruses, nanoparticles, single …

During the last years, X-ray free electron lasers (XFELs) have emerged as X-ray sources of
unparalleled brightness, delivering extreme amounts of photons in femtosecond pulses. As …

X-ray free-electron lasers (XFELs) enable crystallographic structure determination beyond
the limitations imposed upon synchrotron measurements by radiation damage. The need for …

With the emergence of X-ray free-electron lasers (XFELs), coherent diffractive imaging (CDI)
has acquired a capability for single-particle imaging (SPI) of non-crystalline objects under …

Single particle imaging at x-ray free electron lasers (XFELs) has the potential to determine
the structure and dynamics of single biomolecules at room temperature. Two major hurdles …

Intense x-ray free-electron laser (XFEL) pulses hold great promise for imaging function in
nanoscale and biological systems with atomic resolution. So far, however, the spatial …

The noise caused by sample heterogeneity (including sample solvent) has been identified
as one of the determinant factors for a successful X-ray single-particle imaging experiment. It …

We present a computational case study of X-ray single-particle imaging of hydrated proteins
on an example of 2-Nitrogenase–Iron protein covered with water layers of various thickness …

The routine atomic resolution structure determination of single particles is expected to have
profound implications for probing structure–function relationships in systems ranging from …

X-ray free-electron lasers (XFELs) have the ability to produce ultra-bright femtosecond X-ray
pulses for coherent diffraction imaging of biomolecules. While the development of methods …