Hepatocellular carcinoma immune landscape and the potential of immunotherapies
Hepatocellular carcinoma (HCC) is the most common liver tumor and among the deadliest
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …
[HTML][HTML] Targeting immune cells in the tumor microenvironment of HCC: new opportunities and challenges
X Hao, G Sun, Y Zhang, X Kong, D Rong… - Frontiers in cell and …, 2021 - frontiersin.org
Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …
development and progression of hepatocellular carcinoma (HCC) and have received more …
Tumor immunoediting and immunosculpting pathways to cancer progression
JM Reiman, M Kmieciak, MH Manjili… - Seminars in cancer …, 2007 - Elsevier
Recent studies have suggested that a natural function of the immune system is to respond
and destroy aberrant, dysfunctional cells by a process called immunosurveillance. These …
and destroy aberrant, dysfunctional cells by a process called immunosurveillance. These …
Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma
AJ Gehring, ZZ Ho, AT Tan, MO Aung, KH Lee, KC Tan… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Tumor and viral antigens are expressed by hepatocellular
carcinoma (HCC) in patients with chronic hepatitis B, but little is known about the …
carcinoma (HCC) in patients with chronic hepatitis B, but little is known about the …
Immune cell therapy for hepatocellular carcinoma
E Mizukoshi, S Kaneko - Journal of hematology & oncology, 2019 - Springer
Given the success of immune checkpoint inhibitors and chimeric antigen receptor (CAR) T
cells in clinical settings, the host immune system plays an important role in the recognition …
cells in clinical settings, the host immune system plays an important role in the recognition …
Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trial
N Leffers, AJA Lambeck, MJM Gooden… - … Journal of Cancer, 2009 - Wiley Online Library
The prognosis of ovarian cancer, the primary cause of death from gynecological
malignancies, has only modestly improved over the last decades. Immunotherapy is one of …
malignancies, has only modestly improved over the last decades. Immunotherapy is one of …
Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy
Y Umemoto, S Okano, Y Matsumoto… - Journal of …, 2015 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most common solid tumors
worldwide. Surgery is potentially curative, but high recurrence rates worsen patient …
worldwide. Surgery is potentially curative, but high recurrence rates worsen patient …
Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of …
IM Svane, AE Pedersen, JS Johansen… - Cancer Immunology …, 2007 - Springer
Abstract p53 mutations are found in up to 30% of breast cancers and peptides derived from
over-expressed p53 protein are presented by class I HLA molecules and may act as tumor …
over-expressed p53 protein are presented by class I HLA molecules and may act as tumor …
Intratumoral T cells, tumor-associated macrophages, and regulatory T cells: association with p53 mutations, circulating tumor DNA and survival in women with ovarian …
OBJECTIVES: Forty percent of women with ovarian cancer have circulating free tumor DNA.
We sought to determine if the tumor immune infiltrate varied based on tumor p53 mutation …
We sought to determine if the tumor immune infiltrate varied based on tumor p53 mutation …
Natural immunity to pluripotency antigen OCT4 in humans
KM Dhodapkar, D Feldman… - Proceedings of the …, 2010 - National Acad Sciences
OCT4 is a transcription factor critical for the pluripotency of human embryonal stem (ES) and
induced pluipotency stem (IPS) cells. OCT4 is commonly expressed in germ-cell tumors as …
induced pluipotency stem (IPS) cells. OCT4 is commonly expressed in germ-cell tumors as …