Antifungal drugs: the current armamentarium and development of new agents
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
Functions of sphingolipids in pathogenesis during host–pathogen interactions
J Wang, YL Chen, YK Li, DK Chen, JF He… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …
Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids
Recent estimates suggest that> 300 million people are afflicted by serious fungal infections
worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of …
worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of …
Sphingolipids as targets for treatment of fungal infections
R Rollin-Pinheiro, A Singh… - Future medicinal …, 2016 - Taylor & Francis
Invasive fungal infections have significantly increased in the last few decades. Three classes
of drugs are commonly used to treat these infections: polyenes, azoles and echinocandins …
of drugs are commonly used to treat these infections: polyenes, azoles and echinocandins …
Recent progress in the strategic incorporation of fluorine into medicinally active compounds
This account exemplifies our recent progress on the strategic incorporation of fluorine and
organofluorine groups to (i) taxoid anticancer agents,(ii) acylhydrazone-based antifungal …
organofluorine groups to (i) taxoid anticancer agents,(ii) acylhydrazone-based antifungal …
Synthesis and biological properties of fungal glucosylceramide
Sphingolipids have recently emerged as key regulators of pathogenicity in a variety of fungi.
Glucosylceramide is a sphingolipid important for fungal cell division, alkaline tolerance …
Glucosylceramide is a sphingolipid important for fungal cell division, alkaline tolerance …
Old and new strategies in therapy and diagnosis against fungal infections
T Vanzolini, M Magnani - Applied Microbiology and Biotechnology, 2024 - Springer
Fungal infections represent a serious global health threat. The new emerging pathogens
and the spread of different forms of resistance are now hardly challenging the tools available …
and the spread of different forms of resistance are now hardly challenging the tools available …
[HTML][HTML] Beyond membrane components: uncovering the intriguing world of fungal sphingolipid synthesis and regulation
Sphingolipids (SLs) are essential to fungal survival and represent a major class of structural
and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous …
and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous …
Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans
In previous studies we showed that the replication of Cryptococcus neoformans in the lung
environment is controlled by the glucosylceramide (GlcCer) synthase gene (GCS1), which …
environment is controlled by the glucosylceramide (GlcCer) synthase gene (GCS1), which …
Vesicular transport systems in fungi
Canonical and unconventional mechanisms of secretion in many eukaryotic cells are
relatively well known. In contrast to the situation in animal cells, mechanisms of secretion in …
relatively well known. In contrast to the situation in animal cells, mechanisms of secretion in …