Background Insulin resistance has been associated with metabolic and hemodynamic
alterations and higher cardio metabolic risk. There is great variability in the threshold …

Abstract The Youden Index is a frequently used summary measure of the ROC (Receiver
Operating Characteristic) curve. It both, measures the effectiveness of a diagnostic marker …

The use of biomarkers is of ever-increasing importance in clinical diagnosis of disease. In
practice, a cutpoint is required for dichotomizing naturally continuous biomarker levels to …

In this review, we present an overview of the main aspects related to the statistical
evaluation of medical tests for diagnosis and prognosis. Measures of diagnostic …

Screening with digital breast tomosynthesis (DBT) improves breast cancer detection and
reduces false positives. However, currently, no breast cancer risk model takes advantage of …

In this paper we review the literature on ROC curves in the presence of covariates. We
discuss the different approaches that have been proposed in the literature to define, model …

Objective. To determine the optimal cutoff of the homeostasis model assessment‐insulin
resistance (HOMA‐IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and …

Abstract The Youden Index is often used as a summary measure of the receiver operating
characteristic curve. It measures the effectiveness of a diagnostic marker and permits the …

Background Hyperoxia is associated with increased morbidity and mortality in the intensive
care unit. Classical noninvasive measurements of oxygen saturation with pulse oximeters …

Objectives To introduce a new, patient-oriented predictive index as a measure of gain in
certainty. Study design Algebraic equations. Results A new measure is suggested based on …